Detection and size estimation of acute myocardial infarction using /sup 99m/ Tc-glucoheptonate

Journal Article · Fri Oct 31 23:00:00 EST 1975 · J. Nucl. Med., v. 16, no. 11, pp. 980-985

OSTI ID:4158263

Rossman, D J; Rouleau, J; Strauss, H W; Pitt, B

Twenty-seven patients with suspected acute myocardial infarction were studied by precordial scanning after intravenous administration of /sup 99m/Tc- glucoheptonate 2--48 hr after the onset of chest pain. Fifteen of the patients had clinically documented acute myocardial infarctions. Twelve of these 15 (80 percent) had areas of distinctly increased tracer uptake in the region of the heart. The three infarctions not identified by scan had peak serum CPK values of less than 300. In seven patients without infarction, no distinct areas of increased tracer uptake were found in the region of the heart. Five patients could not be classified as to whether infarction had or had not occurred. Three had abnormal scans, the significance of which is uncertain. Infarct size was estimated from the area of increased /sup 99m/Tc-glucoheptonate concentration on scan and compared to peak serum CPK values. A linear correlation with a correlation coefficient of 0.77 was found. Technetium-99m-glucoheptonate scanning was useful for the identification and size estimation of moderate- to large-sized transmural and nontransmural acute myocardial infarctions. (auth)

• Research Organization: Johns Hopkins Medical Institutes, Baltimore
• NSA Number: NSA-33-007708
• OSTI ID: 4158263
• Journal Information: J. Nucl. Med., v. 16, no. 11, pp. 980-985, Journal Name: J. Nucl. Med., v. 16, no. 11, pp. 980-985; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

*HEART-- SCINTISCANNING
*MYOCARDIAL INFARCTION-- DIAGNOSTIC TECHNIQUES
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
ISOMERIC NUCLEI
LABELLED COMPOUNDS
N48830* --Life Sciences--New Tracer Techniques--Other
NUCLEAR MEDICINE
PATIENTS
RADIONUCLIDE ADMINISTRATION