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Effect of coronary blood flow and site of injection on Tc-99m PPi detection of early canine myocardial infarcts

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6643769
; ; ; ; ; ; ; ;
The effect of blood flow and site of injection on Tc-99m PPi uptake in acute myocardial infarction was studied in a group of 24 dogs. Temporary (3 hr) and permanent LAO occlusion models were used. Animals with the temporary occlusions showed scintigraphic visualization of the infarcts and reversal of the normal epito-endocardial Tc-99m PPi ratio in contrast to those with permanent coronary occlusions. The data demonstrate that early (within 3 hr) experimental canine myocardial infarcts can be detected with Tc-99m PPi if reflow to the area of infarction is provided. Delayed development of abnormal Tc-99m PPi scintigrams with acute infarction is related primarily to the initial lack of adequate blood flow to the damaged tissue, with subsequent development of adequate collateral flow allowing delivery and uptake of sufficient amount of the radiopharmaceutical for in vivo scintigraphic detection of the damaged area(s).
Research Organization:
Univ. of Texas, Dallas
OSTI ID:
6643769
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:2; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
BLOOD FLOW
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
CORONARIES
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DOGS
ESTERS
HEART
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHORIC ACID ESTERS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPONSE MODIFYING FACTORS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
UPTAKE
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES