Dosimetry of D- and L-enantiomers of /sup 11/C-labeled tryptophan and valine
Conference
·
OSTI ID:5149565
We have previously reported the radiation dosimetry of /sup 11/C-labeled DL-tryptophan and DL-valine, as well as clinical pancreatic imaging studies with these agents. Because of significant uptake in both normal pancreas and in pancreatic tumors (thought to be due to the presence of the D-enantiomer), differential diagnosis of pancreatic carcinoma was not feasible. High-performance liquid chromatographic (HPLC) methods were developed for rapid resolution of /sup 11/C-labeled DL-tryptophan and DL-valine. Radiation dose estimates to the various organs in man were calculated for the D- and L-enantiomers of /sup 11/C-labeled tryptophan and valine, based on tissue distribution data in rats. The dose estimates were sufficiently low that 20-mCi doses of each of the enantiomeric amino acids were approved by the FDA for intravenous administration to humans. 21 refs., 3 tabs.
- Research Organization:
- Oak Ridge Associated Universities, Inc., TN (USA)
- DOE Contract Number:
- AC05-76OR00033
- OSTI ID:
- 5149565
- Report Number(s):
- CONF-851113-8; ON: DE87000311
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
AROMATICS
AZAARENES
AZOLES
BODY
BONE MARROW
BRAIN
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHROMATOGRAPHY
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOSES
DRUGS
ENDOCRINE GLANDS
FEMALE GENITALS
FRACTIONATION
GASTROINTESTINAL TRACT
GLANDS
GONADS
HEART
HEMATOPOIETIC SYSTEM
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
INTESTINES
KIDNEYS
LABELLED COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
LIVER
LUNGS
MALE GENITALS
MAMMALS
MUSCLES
NEOPLASMS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OVARIES
PANCREAS
PYRROLES
RADIATION DOSES
RADIOPHARMACEUTICALS
RATS
RESPIRATORY SYSTEM
RODENTS
SEPARATION PROCESSES
SMALL INTESTINE
SPLEEN
TESTES
TISSUE DISTRIBUTION
TISSUES
TRYPTOPHAN
VALINE
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
AROMATICS
AZAARENES
AZOLES
BODY
BONE MARROW
BRAIN
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHROMATOGRAPHY
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOSES
DRUGS
ENDOCRINE GLANDS
FEMALE GENITALS
FRACTIONATION
GASTROINTESTINAL TRACT
GLANDS
GONADS
HEART
HEMATOPOIETIC SYSTEM
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
INTESTINES
KIDNEYS
LABELLED COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
LIVER
LUNGS
MALE GENITALS
MAMMALS
MUSCLES
NEOPLASMS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OVARIES
PANCREAS
PYRROLES
RADIATION DOSES
RADIOPHARMACEUTICALS
RATS
RESPIRATORY SYSTEM
RODENTS
SEPARATION PROCESSES
SMALL INTESTINE
SPLEEN
TESTES
TISSUE DISTRIBUTION
TISSUES
TRYPTOPHAN
VALINE
VERTEBRATES