Dosimetry of D- and L-enantiomers of /sup 11/C-labeled tryptophan and valine
We have previously reported the radiation dosimetry of /sup 11/C-labeled DL-tryptophan and DL-valine, as well as clinical pancreatic imaging studies with these agents. Because of significant uptake in both normal pancreas and in pancreatic tumors (thought to be due to the presence of the D-enantiomer), differential diagnosis of pancreatic carcinoma was not feasible. High-performance liquid chromatographic (HPLC) methods were developed for rapid resolution of /sup 11/C-labeled DL-tryptophan and DL-valine. Radiation dose estimates to the various organs in man were calculated for the D- and L-enantiomers of /sup 11/C-labeled tryptophan and valine, based on tissue distribution data in rats. The dose estimates were sufficiently low that 20-mCi doses of each of the enantiomeric amino acids were approved by the FDA for intravenous administration to humans. 21 refs., 3 tabs.
- Research Organization:
- Oak Ridge Associated Universities, Inc., TN (USA)
- DOE Contract Number:
- AC05-76OR00033
- OSTI ID:
- 5149565
- Report Number(s):
- CONF-851113-8; ON: DE87000311
- Resource Relation:
- Conference: Radiopharmaceutical dosimetry symposium, Oak Ridge, TN, USA, 5 Nov 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
TRYPTOPHAN
FRACTIONATION
TISSUE DISTRIBUTION
VALINE
BONE MARROW
BRAIN
CARBON 14 COMPOUNDS
HEART
KIDNEYS
LIQUID COLUMN CHROMATOGRAPHY
LIVER
LUNGS
MUSCLES
NEOPLASMS
OVARIES
PANCREAS
RADIATION DOSES
RADIOPHARMACEUTICALS
RATS
SMALL INTESTINE
SPLEEN
TESTES
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
AROMATICS
AZAARENES
AZOLES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHROMATOGRAPHY
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOSES
DRUGS
ENDOCRINE GLANDS
FEMALE GENITALS
GASTROINTESTINAL TRACT
GLANDS
GONADS
HEMATOPOIETIC SYSTEM
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
INTESTINES
LABELLED COMPOUNDS
MALE GENITALS
MAMMALS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRROLES
RESPIRATORY SYSTEM
RODENTS
SEPARATION PROCESSES
TISSUES
VERTEBRATES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)