High mortality rates occur in copper deficient rats exposed to a normally nonlethal endotoxin treatment

Conference · Fri Mar 15 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5143910

DiSilvestro, R; Joseph, E; Yang, F L ^[1]

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1. Ohio State Univ., Columbus (United States)

Endotoxin hepatotoxicity is proposed to occur by processes which could be retarded by 3 copper enzymes: ceruloplasmin, Cu-Zn superoxide dismutase (SOD), and extracellular (EC) SOD. Weanling rats fed low copper for 40 days showed low activity levels of these enzymes, and a very high mortality rate 20 h after endotoxin injection. No rats fed adequate copper died from this treatment. In addition, serum transaminase activities, indicators of liver damage, were elevated by 3 h to a greater extent in the deficient rats than in the adequates. The high susceptibility to endotoxemia in the deficient rats was not associated with low hepatic glutathione, high liver malondialedhyde, nor restricted metallothionein induction 3 h after endotoxin injection. Endotoxin reduced serum EC SOD activities in adequate and deficient rats, but final values were lower in the latter. Studies on roles of specific copper enzymes in resistance to endotoxemia are currently underway.

• OSTI ID: 5143910
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:5
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINOTRANSFERASES
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CERULOPLASMIN
COMPLEXES
COPPER
COPPER COMPLEXES
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
ENDOTOXINS
ENZYME ACTIVITY
ENZYMES
GLANDS
GLOBULINS
GLOBULINS-ALPHA
HAZARDOUS MATERIALS
LIVER
MAMMALS
MATERIALS
METABOLIC DISEASES
METABOLISM
METALLOPROTEINS
METALS
MORTALITY
NITROGEN TRANSFERASES
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PATHOGENESIS
PROTEINS
RATS
RODENTS
SUPEROXIDE DISMUTASE
SYNTHESIS
TOXIC MATERIALS
TOXINS
TRANSFERASES
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
VERTEBRATES