Inflammation protects copper deficient rats from carbon tetrachloride toxicity
Conference
·
· FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
OSTI ID:5371973
- Ohio State Univ., Columbus (United States)
Copper deficient rats show low resistance to CCl{sub 4}, possibly due to low liver Cu-Zn superoxide dismutase (SOD) activities. If Cu-Zn SOD is involved, deficiency effects should be aggravated by inflammation which further lowers Cu-Zn SOD activities in deficient rats. On the contrary, inflammation from 0.1 ml turpentine (im, lef) protected these rats from CCl{sub 4} damage assessed by serum activities of 2 liver enzymes. CCl{sub 4} was given ip at 200 {mu}l/kg, 48 h after turpentine, 24 h before sacrifice. Rats were fed low copper for 40 days before CCl{sub 4} challenge. Inflammation also protected rats fed adequate copper from injury, though injury in noninflamed rats was less than with noninflamed deficients. Protection could result from the large increase observed in liver metallothionein, an induction not restricted by copper deficiency. Alternatively, inflammation may block P-450 activation of CCl{sub 4}. Both explanations are currently under investigation, as is the role, if any, of Cu-Zn SOD in resisting CCl{sub 4} injury.
- OSTI ID:
- 5371973
- Report Number(s):
- CONF-9104107--
- Conference Information:
- Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL FUNCTIONS
BODY
CARBON TETRACHLORIDE
CHLORINATED ALIPHATIC HYDROCARBONS
COPPER
DIGESTIVE SYSTEM
ELEMENTS
ENZYME ACTIVITY
ENZYMES
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
INFLAMMATION
LIVER
MAMMALS
METALLOPROTEINS
METALLOTHIONEIN
METALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC SOLVENTS
ORGANS
OXIDOREDUCTASES
PATHOLOGICAL CHANGES
PROTEINS
RATS
RODENTS
SOLVENTS
SUPEROXIDE DISMUTASE
SYMPTOMS
TERPENES
TOXICITY
TRANSITION ELEMENTS
TURPENTINE
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL FUNCTIONS
BODY
CARBON TETRACHLORIDE
CHLORINATED ALIPHATIC HYDROCARBONS
COPPER
DIGESTIVE SYSTEM
ELEMENTS
ENZYME ACTIVITY
ENZYMES
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
INFLAMMATION
LIVER
MAMMALS
METALLOPROTEINS
METALLOTHIONEIN
METALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC SOLVENTS
ORGANS
OXIDOREDUCTASES
PATHOLOGICAL CHANGES
PROTEINS
RATS
RODENTS
SOLVENTS
SUPEROXIDE DISMUTASE
SYMPTOMS
TERPENES
TOXICITY
TRANSITION ELEMENTS
TURPENTINE
VERTEBRATES