Copper status in weanling rats fed low levels of inorganic tin

Conference · Fri Mar 15 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5239267

Rader, J I; Hight, S C ^[1]

---

1. Food and Drug Administration, Washington, DC (United States)

The metabolism of Cu and Fe is adversely affected by ingestion of tin (Sn). In the present study, weanling male rats were fed 33 ug Sn/g in purified Cu-adequate or Cu-deficient diets for 14 or 28 days. Diets were based upon diet AIN-76A and contained 55% glucose and 15% starch. Ceruloplasmin was undetectable in serum of rats fed diets 2, 3 and 4 for 14 or 28 days. Superoxide dismutase (SOD) and Cu in liver decreased when 33 ug Sn/g was included in +Cu diets. Wt. gain, relative heart wt., SOD, and Cu and Fe in liver were sensitive indices of copper depletion in rats fed {minus}Cu diets. Cu status in rats fed {minus}Cu diets for 14 or 28 days was adversely affected by inclusion of Sn as indicated by changes in hemoglobin (HGB) and relative heart wt. Ingestion of low levels of inorganic tin causes Cu depletion in rats fed +Cu diets and accelerated the appearance of signs of copper deficiency in those fed {minus}Cu diets.

• OSTI ID: 5239267
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:5
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
CERULOPLASMIN
COMPLEXES
COPPER
COPPER COMPLEXES
ELEMENTS
ENZYMES
GLOBULINS
GLOBULINS-ALPHA
MAMMALS
METABOLISM
METALLOPROTEINS
METALS
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PROTEINS
RATS
RODENTS
SUPEROXIDE DISMUTASE
TIN
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
VERTEBRATES