Protection against hyperoxia by serum from endotoxin treated rats: absence of superoxide dismutase induction

Journal Article · Thu Dec 31 23:00:00 EST 1987 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-187-1-RC1· OSTI ID:6993500

Berg, J T; Smith, R M

Endotoxin greatly reduces lung injury and pleural effusions in adult rats exposed to normobaric hyperoxia (> 98% oxygen for 60 hours). This study reports that serum from endotoxin treated donor rats protects serum recipients against hyperoxic lung injury without altering lung superoxide dismutase (SOD) activity. Rats pretreated with endotoxin alone were protected and exhibited an increase in lung SOD activity as previously reported by others. Protection by serum was not due to the transfer of residual endotoxin or SOD. These results show, that protection from oxygen toxicity can occur in rats without an increase in lung SOD and suggest that a serum factor may be involved.

• Research Organization: Univ. of Hawaii, Honolulu (USA)
• OSTI ID: 6993500
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Journal Issue: 1 Vol. 187:1; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BLOOD SERUM
BODY
ELEMENTS
ENDOTOXINS
ENZYMES
LUNGS
MAMMALS
MATERIALS
NONMETALS
ORGANS
OXIDOREDUCTASES
OXYGEN
RATS
RESPIRATORY SYSTEM
RODENTS
SUPEROXIDE DISMUTASE
TOXIC MATERIALS
TOXICITY
TOXINS
VERTEBRATES