Ozone-induced tolerance to hyperoxia in rats

Journal Article · Thu Mar 01 04:00:00 EST 1984 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:7132540

Jackson, R M; Frank, L

Preexposure of adult rats to ozone (0.8 +/- 0.1 ppm for 7 days) has been found to produce a marked degree of tolerance to hyperoxia (greater than 95% O2). The survival of O/sub 3/-preexposed rats in hyperoxia for 168 h was 28 of 32 (88%) compared with a rate of 2 of 18 (11%) for nonpreexposed rats. Total lung superoxide dismutase (SOD), glutathione peroxidase (GP), glucose 6-phosphate dehydrogenase (G6-PD), and catalase (CAT) activities were all significantly increased after O/sub 3/ preexposure and after the subsequent hyperoxic challenge. Probable mechanisms accounting for the markedly improved survival in hyperoxia after O/sub 3/ preexposure include both increased lung antioxidant enzyme and repair of structural damage by proliferation of alveolar lining cells. The demonstration of cross-tolerance between the atmospheric oxidants O/sub 3/ and O/sub 2/ suggests that there are similarities in the lung's adaptation to both oxidants.

• Research Organization: University of Miami School of Medicine, Pulmonary Division, Oak Asthma Research and Treatment Facility, Florida
• OSTI ID: 7132540
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 129:3; ISSN ARRDA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CATALASE
ELEMENTS
ENZYME ACTIVITY
ENZYMES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
MAMMALS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
OXYGEN
OZONE
PEROXIDASES
PORPHYRINS
RATS
RESPIRATION
RODENTS
SUPEROXIDE DISMUTASE
TOLERANCE
VERTEBRATES