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Determination of trimethylselenonium ion in urine by ion-exchange chromatography and molecular neutron activation analysis

Journal Article · · Anal. Chem.; (United States)
DOI:https://doi.org/10.1021/ac00286a033· OSTI ID:5135362

A method has been developed for the determination of the trimethylselenonium ion (TMSe) in urine by anion exchange-cation exchange chromatography, selectively capturing the TMSe on the cation exchange resin. TMSe recoveries are 91.9 +/- 7.6%. The TMSe fraction is irradiated with neutrons and radioassayed for /sup 77m/Se activity. Various experimental procedures including acid hydrolysis, nitric acid digestion, and HPLC were evaluated in order to optimize the determination. 23 references, 3 figures, 5 tables.

Research Organization:
V.A. Medical Center, Omaha, NE
DOE Contract Number:
FG02-84ER13231
OSTI ID:
5135362
Journal Information:
Anal. Chem.; (United States), Journal Name: Anal. Chem.; (United States) Vol. 57:9; ISSN ANCHA
Country of Publication:
United States
Language:
English