Biochemical bases of action of radioprotective agents

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:5134259

Romantsev, E F; Blokhina, V D; Zhulanova, Z I; Koshcheenko, N N; Filippovich, I V

Inhibition of radiosensitive biochemical processes, DNA replication, RNA and protein biosynthesis, oxidative phosphorylation is observed shortly after giving animals radioprotective doses of aminothiols. The molecular mechanisms of the observed phenomena consist of the capacity of aminothiol radioprotective agents to form adsorption, thioester, amide and disulfide bonds with specific enzyme proteins. The curve reflecting the kinetics of formation of mixed disulfide bonds between aminothiols and proteins coincides completely with the curve reflecting the radioprotective effect as function of time of administration of the radioprotective agent. Mixed disulfides are of decisive significance in inhibition of biochemical processes that determine the radioprotective effect. The radiobiological importance of the observed molecular interactions can be perceived as decreased build-up of ''defective'' molecules (inhibition of replication) and alleviation of repair processes. The inhibition of biochemical processes is brief and reversible. Radioprotective agents, the mechanism of action of which is related to the so-called oxygen effect, also exert their radioprotective action by means of biochemical mechanisms.

• OSTI ID: 5134259
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 17:5; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

560151 -- Radiation Effects on Animals-- Man
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOCHEMICAL REACTION KINETICS
BIOSYNTHESIS
CHEMICAL REACTIONS
DNA REPLICATION
DRUGS
INHIBITION
KINETICS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PHOSPHORYLATION
PROTEINS
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
RESPONSE MODIFYING FACTORS
RNA
SYNTHESIS