The effect of radioprotective agents on tissue nonprotein sulfhydryl and disulfide levels
Journal Article
·
· Archives of Biochemistry and Biophysics
Reaction mechanisms involved in the radioprotective effects of aminoethylthiosulfuric acid and aminoethylthiophosphate in mice were investigated. The thioesters were injected into irradiated and control mice and the nonprotien sulfhydryl and disulfide content of spleen, liver, and blood were determined. Results were compared with those using other protective and nonprotective compounds. Results indicate that anninoethylthiosulfuric acid and aniinoethylthiophosphate are converted in vivo to cysteamine, which then may be the effective protective agent.
- Research Organization:
- Medical Nobel Inst., Stockholm; Research Inst. of National Defense, Sundbyberg, Sweden
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-028836
- OSTI ID:
- 4791605
- Journal Information:
- Archives of Biochemistry and Biophysics, Journal Name: Archives of Biochemistry and Biophysics Journal Issue: 2 Vol. 98; ISSN 0003-9861
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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