Involvement of cAMP in the radioprotective effect

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:5205518

Kudryashov, Yu B; Sobolev, A S

It was experimentally demonstrated that radioprotective agents affect the cAMP system. It is assumed that a ''cascade'' mechanism is involved in the action of radioprotective agents on biochemical processes in the animal organism. The first cascade is activation of synthesis and removal of endogenous amines from tissues under the influence of radioprotectors. Endogenous amines stimulate adenylate cyclase of radiation-injured tissues, thereby triggering the second cascade, the cAMP system, which controls many processes impaired by radiation. Analysis of the literature warrants the belief that the increase in cAMP concentration in eukaryote cells is related to an increase in radioresistance thereof.

• Research Organization: Moscow State Univ.
• OSTI ID: 5205518
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 17:5; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AMP
BIOCHEMICAL REACTION KINETICS
DRUGS
KINETICS
NUCLEOTIDES
ORGANIC COMPOUNDS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
REACTION KINETICS
RESPONSE MODIFYING FACTORS