Comparative study of radioprotective activity and mechanism of action of 2-mercaptopropionylglycine and. beta. -mercaptoethylamine. [Mice, gamma radiation]

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:6787583

Konstantinova, M M; Revez, L

As a result of studying the radioprotective activity of 2-mercaptopropionylglycine (MPG), it was established that this compound has marked radioprotective activity in mice and Ehrlich ascites carcinoma cells in vitro. The mechanism of radioprotective action of MPG on animals, as that of other sulfhydryl compounds (MEA--cysteamine), is not related to the oxygen effect, but to the influence thereof on the level of endogenous thiols. Analysis of the mechanism of radioprotective effects of MPG and MEA, performed on cells, revealed that the increase in radioresistance induced by these agents is determined by an increase in endogenous SH glutathione elicited by administration of protective agents, rather than the presence of such agents in cells.

• Research Organization: Inst. of Developmental Biology, Moscow
• OSTI ID: 6787583
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 17:6; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMALS
ASCITES TUMOR CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IONIZING RADIATIONS
MAMMALS
MEA
MICE
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
THIOLS
TUMOR CELLS
VERTEBRATES