Investigation of the role of endogenous serotonin in the mechanism of action of radioprotective agents. Report 2. Effect of norepinephrine on radioresistance of cells and endogenous serotonin level thereof
A comparison of changes induced by ..beta..-mercaptoethylamine in radioresistance and endogenous serotonin content of tumor cells, bone marrow CFU (colony-forming units) and E. coli B bacteria revealed a correlation between these parameters only in Ehrlich ascites tumor cells. Previously, such a correlation was also demonstrated with this protective agent in experiments on E. coli. The contradictory nature of the data and difficulty of interpreting them when evaluating the role of endogenous serotonin in the mechanism of action of radioprotective agents prompted this study to examine the correlation between radioresistance and endogenous serotonin levels in different types of cells using another protective agent, norepinephrine.
- Research Organization:
- Inst. of Developmental Biology, Moscow, USSR
- OSTI ID:
- 5389197
- Journal Information:
- Radiobiology (USSR) (Engl. Transl.); (United States), Vol. 18:3; Other Information: Translated from Radiobiologiya; 18: No. 3, 435-437(1978)
- Country of Publication:
- United States
- Language:
- English
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Investigation of the role of endogenous serotonin in the mechanism of action of radioprotective agents. Report 3. Lack of correlation between altered radiosensitivity of cells and change in their endogenous serotonin content
Radioresistance of cells of different E. coli strains and endogenous serotonin content thereof
Related Subjects
ASCITES TUMOR CELLS
RADIOSENSITIVITY
BONE MARROW CELLS
ESCHERICHIA COLI
NORADRENALINE
RADIOSENSITIVITY EFFECTS
SEROTONIN
BIOLOGICAL PATHWAYS
EXPERIMENTAL DATA
GRAPHS
MEA
SURVIVAL CURVES
TABLES
ADRENAL HORMONES
AMINES
ANIMAL CELLS
AZOLES
BACTERIA
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DRUGS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
INDOLES
INFORMATION
MICROORGANISMS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
SOMATIC CELLS
STEROID HORMONES
SYMPATHOMIMETICS
THIOLS
TRYPTAMINES
TUMOR CELLS
560121* - Radiation Effects on Cells- External Source- (-1987)
560131 - Radiation Effects on Microorganisms- Basic Studies- (-1987)