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Investigation of the role of endogenous serotonin in the mechanism of action of radioprotective agents. Report 2. Effect of norepinephrine on radioresistance of cells and endogenous serotonin level thereof

Journal Article · · Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5389197
; ; ; ;
A comparison of changes induced by ..beta..-mercaptoethylamine in radioresistance and endogenous serotonin content of tumor cells, bone marrow CFU (colony-forming units) and E. coli B bacteria revealed a correlation between these parameters only in Ehrlich ascites tumor cells. Previously, such a correlation was also demonstrated with this protective agent in experiments on E. coli. The contradictory nature of the data and difficulty of interpreting them when evaluating the role of endogenous serotonin in the mechanism of action of radioprotective agents prompted this study to examine the correlation between radioresistance and endogenous serotonin levels in different types of cells using another protective agent, norepinephrine.
Research Organization:
Inst. of Developmental Biology, Moscow, USSR
OSTI ID:
5389197
Journal Information:
Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:3; ISSN RADBA
Country of Publication:
United States
Language:
English

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Investigation of the role of endogenous serotonin in the mechanism of action of radioprotective agents. Report 1. Role of endogenous serotonin in enhancing radioresistance of different types of cells treated with. beta. -mercaptoethylamine. [X rays; bone marrow cells; Ehrlich ascites tumor cells; Escherichia coli]
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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560131 -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
AMINES
ANIMAL CELLS
ASCITES TUMOR CELLS
AZOLES
BACTERIA
BIOLOGICAL PATHWAYS
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DRUGS
ESCHERICHIA COLI
EXPERIMENTAL DATA
GRAPHS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
INDOLES
INFORMATION
MEA
MICROORGANISMS
NORADRENALINE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
SEROTONIN
SOMATIC CELLS
STEROID HORMONES
SURVIVAL CURVES
SYMPATHOMIMETICS
TABLES
THIOLS
TRYPTAMINES
TUMOR CELLS