Comparison of Herpes simplex virus plaque development after viral treatment with anti-DNA or antilipid agents

Journal Article · Sun Jun 01 04:00:00 EDT 1980 · Biophys. J.; (United States)

DOI:https://doi.org/10.1016/S0006-3495(80)85111-3· OSTI ID:5126268

Coohill, T P; Babich, M; Taylor, W D; Snipes, W

The plaque development of Herpes simplex virus type 1 (HSV) is slower for viruses treated with two anti-DNA agents: ultraviolet radiation (uv) or n-acetoxy-2-acetyl-aminofluorene. For HSV treated with three antimembrane agents - butylated hydroxytoluene, acridine plus near uv radiation, or ether - the plaque development time is the same as for untreated viruses. These differences hold even for viruses that survived treatment that lowered viability below the 1% level. Gamma ray inactivation of HSV produces no change in plaque development even though this agent is believed to preferentially affect viral DNA.

• Research Organization: Western Kentucky Univ., Bowling Green
• OSTI ID: 5126268
• Journal Information: Biophys. J.; (United States), Journal Name: Biophys. J.; (United States) Vol. 30:3; ISSN BIOJA
• Country of Publication: United States
• Language: English

Related Subjects

550700 -- Microbiology
560132* -- Radiation Effects on Microorganisms-- Food Preservation-- (-1987)
560302 -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRIDINES
AROMATICS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CONDENSED AROMATICS
DISEASES
DNA
ELECTROMAGNETIC RADIATION
FLUORENE
GAMMA RADIATION
HERPES SIMPLEX
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
HYDROXY COMPOUNDS
INFECTIOUS DISEASES
IONIZING RADIATIONS
MEMBRANES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PLAQUE FORMATION
PYRIDINES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
SKIN DISEASES
TIME DEPENDENCE
TOLUENE
ULTRAVIOLET RADIATION