Comparison of pulmonary biochemical effects of low-level ozone exposure on mice and rats

Journal Article · Sat May 01 04:00:00 EDT 1982 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398209530208· OSTI ID:5125708

Mustafa, M G; Elsayed, N M; Quinn, C L; Postlethwait, E M; Gardner, D E; Graham, J A

The biochemical effects of a 5-d continuous exposure to 0.45 ppm (882 ..mu..g/m/sup 3/) O/sub 3/ were studied in the lungs of 2-mo-old male, specific-pathogen-free mice (Swiss Webster) and three strains of rats (Long-Evans, Wistar, and Sprague-Dawley). The results, expressed per lung, indicated a general increase in lung weight, DNA and protein contents, oxygen consumption, sulfhydryl metabolism, and the activities of several NADP/sup +/-reducing enzymes for all exposed animals relative to their controls. When the increases in the two species (mice versus three strains of rats) were compared, the mice showed significantly higher increases than the rats in several parameters. The responses among the three strains of rats were variable, but the differences were not significant. These observations suggest that Swiss Webster mice may offer a more sensitive animal model than rats for studying the pulmonary effects of a given low-level O/sub 3/ exposure.

• Research Organization: Univ. of California, Los Angeles
• OSTI ID: 5125708
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 9:5-6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BODY
COMPARATIVE EVALUATIONS
LUNGS
MAMMALS
MICE
ORGANS
OZONE
RATS
RESPIRATORY SYSTEM
RODENTS
SENSITIVITY
VERTEBRATES