Functional and biochemical indicators of pneumoconiosis in mice: comparison with rats

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398409530514· OSTI ID:5927501

Hatch, G E; Raub, J A; Graham, J A

Mice were injected intratracheally with silica or Mt. St. Helens volcanic ash (0.2 mg/g body weight) and examined 6 months later for changes in pulmonary function, histology, and hydroxyproline content. Results were compared with a similar study using rats. Mice injected with volcanic ash showed significant changes only in wet lung weights. Those injected with silica showed an approximate doubling of lung wet weight and dry weight and hydroxyproline content. Larger increases in lung weight were seen if lymph nodes were left attached. Lung compliance, total lung capacity, and the shape of the pressure-volume curves of the lung were changed as much as 22% in the silica-treated mice. A mild degree of fibrosis with no dense lung consolidation was noted microscopically in silica-treated mice. In contrast, silica-treated rats showed dense lung consolidation, threefold to fivefold increases in both wet and dry lung weights and hydroxyproline content, and up to 40% reductions in pulmonary function measurements. It is concluded that Swiss albino mice developed a milder degree of fibrosis than similarly treated Sprague-Dawley rats and that both biochemical and functional indicators are effective in detecting pneumoconiosis in these species. 32 references, 1 figure, 3 tables.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC
• OSTI ID: 5927501
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 13:4-6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AMINO ACIDS
ANIMALS
AZOLES
BIOLOGICAL INDICATORS
BIOLOGICAL MODELS
BIOLOGICAL VARIABILITY
BODY
CARBOXYLIC ACIDS
CASCADE MOUNTAINS
CHALCOGENIDES
DATA
DISEASES
DUSTS
DYNAMIC FUNCTION STUDIES
EXPERIMENTAL DATA
FEDERAL REGION X
FIBROSIS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HISTOLOGY
HYDROXY ACIDS
HYDROXYPROLINE
INFORMATION
INTRATRACHEAL ADMINISTRATION
LUNGS
MAMMALS
MICE
MINERALS
MOUNTAINS
MT ST HELENS
NORTH AMERICA
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PNEUMOCONIOSES
PYRROLES
PYRROLIDINES
RATS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RODENTS
SILICA
SILICON COMPOUNDS
SILICON OXIDES
TOXICITY
USA
VERTEBRATES
WASHINGTON
WEIGHT