Long-term reactivity of lung and mediastinal lymph nodes following intratracheal instillation of sandy loam soil or Mount St. Helens volcanic ash

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(83)90205-0· OSTI ID:5928726

Sanders, C L; Rhoads, K; Mahaffey, J A

The effects of Ritzville sandy loam soil and Mount St. Helens volcanic ash particles on the lung and mediastinal lymph nodes of Fischer rats were studied about 400 days after intratracheal instillation. A total of 22 or 77 mg of soil or ash was given in two or seven equally divided, consecutive, weekly intervals as a suspension in 0.5 ml saline. Significantly elevated levels of lipid-phosphorus and protein were found in lung lavages of rats given ash compared to those given soil. An enhanced histological degree of granulomatous reactivity, lipoproteinosis, fibrosis, and bronchiolar hyperplasia was seen in ash-exposed rats as compared to soil-exposed rats. Mediastinal lymph nodes of ash-exposed rats were 8-18 times larger than those of soil-exposed rats due to abundant cellular microgranuloma formation and early fibrosis. Mount St. Helens volcanic ash is apparently more biologically reactive than soil particles commonly found in eastern Washington.

• Research Organization: Pacific Northwest Lab., Richland, WA
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5928726
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 32; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ASHES
BODY
CASCADE MOUNTAINS
FEDERAL REGION X
FLUIDS
GASES
INTRATRACHEAL ADMINISTRATION
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
MOUNTAINS
MT ST HELENS
NORTH AMERICA
ORGANS
PATHOLOGICAL CHANGES
RATS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SOILS
TOXICITY
USA
VERTEBRATES
VOLCANIC GASES
WASHINGTON