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Role of complement in experiment silicosis

Journal Article · · Environ. Res.; (United States)
OSTI ID:5071140
; ; ;
The role of the complement system in the pathogenesis of crystal-induced pulmonary inflammation and fibrosis was evaluated using a mouse model of silicosis and congenitally complement-deficient mice. Mice lacking the fifth component of complement (B10.D2/o) were compared to C5-sufficient animals (B10.D2/n) for pulmonary changes following intratracheal instillation of silica crystals. Complement-deficient mice demonstrated a significant reduction compared to complement-sufficient mice in both cell number and protein content of lung lavage fluid throughout the 12 weeks following silica exposure. Lung hydroxyproline content (indicative of collagen deposition) was equivalent for both strains and significantly higher than controls at all times points following silica instillation. Moreover, studies in vitro have shown that silica crystals are capable of activating complement via the alternative pathway. These studies indicate that the complement system may be responsible for some of the pulmonary inflammation, but not fibrosis elicited by silica exposure.
Research Organization:
Medical College of Wisconsin, Milwaukee
OSTI ID:
5071140
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 40:2; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AMINO ACIDS
ANIMALS
AZOLES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BIOLOGICAL PATHWAYS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHALCOGENIDES
COMPLEMENT
DATA
DISEASES
EXPERIMENTAL DATA
FIBROSIS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY ACIDS
HYDROXYPROLINE
INFLAMMATION
INFORMATION
KINETICS
LAVAGE
LUNGS
MAMMALS
MATERIALS
MICE
MINERALS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PNEUMOCONIOSES
PYRROLES
PYRROLIDINES
REACTION KINETICS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RODENTS
SILICA
SILICON COMPOUNDS
SILICON OXIDES
SYMPTOMS
TOXICITY
VERTEBRATES