Potentiating effects of oxygen in lungs damaged by methylcyclopentadienyl manganese tricarbonyl, cadmium chloride, oleic acid, and antitumor drugs
The intraperitoneal administration of methylcyclopentadienyl manganese tricarbonyl (MMT) and cyclophosphamide, exposure to an aerosol of cadmium chloride, intravenous administration of oleic acid, and intratracheal instillation of bleomycin to young female BALB/c mice or CD/CR rats result in acute lung injury. Pulmonary morphology and lung collagen content were examined in animals treated with these chemicals alone or in combination with an elevated oxygen concentration (80%) in the inspired air. In mice, the development of fibrosis could be significantly enhanced if animals treated with MMT, cadmium chloride, cyclophosphamide, or bleomycin were exposed to 80% oxygen immediately following exposure to these agents. In rats only cyclophosphamide- and bleomycin-induced acute lung injury was potentiated by hyperoxia, resulting in significant enhancement of lung collagen content. The pathogenesis responsible for this differential species response of pulmonary injury to hyperoxia remains to be investigated.
- Research Organization:
- Univ. of Tennessee, Oak Ridge
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6237917
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 67; ISSN TXAPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BLEOMYCIN
BODY
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CARBOXYLIC ACIDS
CHLORIDES
CHLORINE COMPOUNDS
DRUGS
ELEMENTS
ENDOXAN
FIBROSIS
HALIDES
HALOGEN COMPOUNDS
IMMUNOSUPPRESSIVE DRUGS
INJURIES
LUNGS
MAMMALS
MANGANESE COMPOUNDS
MICE
MONOCARBOXYLIC ACIDS
NONMETALS
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXYGEN
PATHOLOGICAL CHANGES
RATS
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RODENTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES