Hyperoxia, but not thoracic X-irradiation, potentiates bleomycin- and cyclophosphamide-induced lung damage in mice
Journal Article
·
· Am. Rev. Respir. Dis.; (United States)
OSTI ID:6941447
The intraperitoneal administration of cyclophosphamide or bleomycin to BALB/c mice resulted in lung cell damage followed by cellular proliferation, which was quantitated by measuring the increase in thymidine incorporation into pulmonary DNA. We have previously shown that administration of the antioxidant butylated hydroxytoluene produces lung damage that can be potentiated by both hyperoxia and thoracic X-irradiation. In the present study we show that hyperoxic exposure also potentiates bleomycin- and cyclophosphamide-induced acute lung damage. However, thoracic X-irradiation does not potentiate bleomycin- and cyclophosphamide-induced lung toxicity.
- Research Organization:
- University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences
- OSTI ID:
- 6941447
- Journal Information:
- Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 126:2; ISSN ARRDA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
ANOXIA
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLEOMYCIN
BODY
CELL PROLIFERATION
DNA
DRUGS
ELECTROMAGNETIC RADIATION
ENDOXAN
HETEROCYCLIC COMPOUNDS
IMMUNOSUPPRESSIVE DRUGS
IONIZING RADIATIONS
LUNGS
MAMMALS
MICE
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RESPIRATORY SYSTEM
RESPIRATORY TRACT CELLS
RIBOSIDES
RODENTS
SENSITIVITY
THYMIDINE
VERTEBRATES
X RADIATION
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
ANOXIA
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLEOMYCIN
BODY
CELL PROLIFERATION
DNA
DRUGS
ELECTROMAGNETIC RADIATION
ENDOXAN
HETEROCYCLIC COMPOUNDS
IMMUNOSUPPRESSIVE DRUGS
IONIZING RADIATIONS
LUNGS
MAMMALS
MICE
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RESPIRATORY SYSTEM
RESPIRATORY TRACT CELLS
RIBOSIDES
RODENTS
SENSITIVITY
THYMIDINE
VERTEBRATES
X RADIATION