A comparison of biochemical effects of nitrogen dioxide, ozone, and their combination in mouse lung

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(84)90251-5· OSTI ID:6830054

Mustafa, M G; Elsayed, N M; von Dohlen, F M; Hassett, C M; Postlethwait, E M; Quinn, C L; Graham, J A; Gardner, D E

Swiss Webster mice were exposed to either 4.8 ppm (9024 microgram/m3) nitrogen dioxide (NO/sub 2/), 0.45 ppm (882 microgram/m3) ozone (O/sub 3/), or their combination intermittently (8 hr daily) for 7 days, and the effects were studied in the lung by a series of physical and biochemical parameters, including lung weight, DNA and protein contents, oxygen consumption, sulfhydryl metabolism, and activities of NADPH generating enzymes. The results show that exposure to NO/sub 2/ caused relatively smaller changes than O/sub 3/, and that the effect of each gas alone under the conditions of exposure was not significant for most of the parameters tested. However, when the two gases were combined, the exposure caused changes that were greater and significant. Statistical analysis of the data shows that the effects of combined exposure were more than additive, i.e., they might be synergistic. The observations suggest that intermittent exposure to NO/sub 2/ or O/sub 3/ alone at the concentration used may not cause significant alterations in lung metabolism, but when the two gases are combined the alterations may become significant.

• Research Organization: Division of Environmental and Occupational Health Sciences, School of Public Health, University of California, Los Angeles
• OSTI ID: 6830054
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 72:1; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
COENZYMES
ENZYME ACTIVITY
LUNGS
MAMMALS
MICE
NADH2
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
OZONE
RESPIRATORY SYSTEM
RODENTS
SYNERGISM
VERTEBRATES