Somatostatin depletion by cysteamine: mechanism and implication for duodenal ulceration

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · Fed. Proc.; (United States)

OSTI ID:5118955

Szabo, S; Reichlin, S

Cysteamine (CSH) and its close derivatives deplete immunoreactive somatostatin (SS) in rat organs. The effect of CSH is dose and time dependent and reversible. Structural requirements of the analogs are the presence of either -SH or -NH2 on a two- or three-carbon alkyl molecule; both radicals together increase, whereas insertion of carboxyl abolishes potency. The duodenal ulcerogenic potency of CSH derivatives is correlated significantly with their SS-depleting activity in the gastric mucosa. The mechanism of this action of CSH is poorly understood, but it is not caused by increased release, enhanced degradation of the peptide, or selective necrosis of SS cells. It is likely that in the intracellular environment CSH causes a conformational change in the peptide that affects the antigenic and functional properties of SS.

• OSTI ID: 5118955
• Journal Information: Fed. Proc.; (United States), Journal Name: Fed. Proc.; (United States) Vol. 9; ISSN FEPRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
CYSTAMINE
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DRUGS
GASTROINTESTINAL TRACT
INTESTINES
MAMMALS
MEMBRANES
MUCOUS MEMBRANES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
SMALL INTESTINE
SOMATOSTATIN
ULCERS
VERTEBRATES