Cysteamine-induced depletion of somatostatin and prolactin

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · Fed. Proc.; (United States)

OSTI ID:5001070

Millard, W J; Sagar, S M; Martin, J B

Cysteamine (2-aminoethanethiol (CSH), given in vivo or in vitro, rapidly but reversibly depletes immunoreactive somatostatin (irSS) in the central nervous system and gut as well as biological and immunological prolactin (PRL) activity in both the anterior pituitary and blood of the rat. This depletion of irSS and PRL is dose dependent and cannot be accounted for by release of either compound. Basal and potassium-stimulated SS release is reduced from hypothalamic tissue in vitro in CSH-treated animals. PRL secretion induced both pharmacologically and physiologically is abolished after CSH administration. Furthermore, CSH reduces cellular PRL content in a number of hyperprolactinemic states. The mechanism by which CSH reduces PRL levels is not clear, but it does not appear to act through the dopamine receptor nor does it alter the morphological structure of the lactotrope in normal animals. Most likely, CSH acts by interacting with the disulfide bonds of PRL, thus rendering the molecule both immunologically and biologically inactive.

• OSTI ID: 5001070
• Journal Information: Fed. Proc.; (United States), Journal Name: Fed. Proc.; (United States) Vol. 9; ISSN FEPRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CYSTAMINE
DRUGS
ELECTROPHORESIS
ENDOCRINE GLANDS
GLANDS
GONADOTROPINS
HORMONES
HYPOTHALAMUS
LTH
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY GLAND
PITUITARY HORMONES
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
SOMATOSTATIN
VERTEBRATES