Effect of cysteamine on cytosolic somatostatin binding sites in rabbit duodenal mucosa
Journal Article
·
· Exp. Mol. Pathol.; (United States)
Administration of cysteamine in rabbits elicited a rapid depletion of both duodenal mucosa and plasma somatostatin. A significant reduction was observed within 5 min, returning toward control values by 150 min. The depletion of somatostatin was associated with an increase in the binding capacity and a decrease in the affinity of both high- and low-affinity binding sites present in cytosol of duodenal mucosa. Incubation of cytosolic fraction from control rabbits with 1 mM cysteamine did not modify somatostatin binding. Furthermore, addition of cysteamine at the time of binding assay did not affect the integrity of /sup 125/I-Tyr11-somatostatin. It is concluded that in vivo administration of cysteamine to rabbits depletes both duodenal mucosa and plasma somatostatin and leads to up-regulation of duodenal somatostatin binding sites.
- Research Organization:
- Universidad de Alcala de Henares, Madrid, Spain
- OSTI ID:
- 6518429
- Journal Information:
- Exp. Mol. Pathol.; (United States), Journal Name: Exp. Mol. Pathol.; (United States) Vol. 2; ISSN EXMPA
- Country of Publication:
- United States
- Language:
- English
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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
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IODINE 125
IODINE COMPOUNDS
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ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MEA
MEMBRANES
MUCOUS MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RABBITS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
SMALL INTESTINE
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THIOLS
TOXICITY
TRACER TECHNIQUES
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GASTROINTESTINAL TRACT
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE 125
IODINE COMPOUNDS
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MEA
MEMBRANES
MUCOUS MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RABBITS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
SMALL INTESTINE
SOMATOSTATIN
THIOLS
TOXICITY
TRACER TECHNIQUES
VERTEBRATES