Lung damage and pulmonary uptake of serotonin in intact dogs

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · J. Appl. Physiol.; (United States)

OSTI ID:5118909

Dawson, C A; Christensen, C W; Rickaby, D A; Linehan, J H; Johnston, M R

The authors examined the influence of glass bead embolization and oleic acid, dextran, and imipramine infusion on the pulmonary uptake of trace doses of (/sup 3/H)serotonin and the extravascular volume accessible to (/sup 14/C)antipyrine in anesthetized dogs. Embolization and imipramine decreased serotonin uptake by 53 and 61%, respectively, but no change was observed with oleic acid or dextran infusion. The extravascular volume accessible to the antipyrine was reduced by 77% after embolization and increased by 177 and approximately 44% after oleic acid and dextran infusion, respectively. The results suggest that when the perfused endothelial surface is sufficiently reduced, as with embolization, the uptake of trace doses of serotonin will be depressed. In addition, decreases in serotonin uptake in response to imipramine in this study and in response to certain endothelial toxins in other studies suggest that serotonin uptake can reveal certain kinds of changes in endothelial function. However, the lack of a response to oleic acid-induced damage in the present study suggests that serotonin uptake is not sensitive to all forms of endothelial damage.

• Research Organization: Veterans Administration Medical Center, Wood, WI
• OSTI ID: 5118909
• Journal Information: J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 6; ISSN JAPYA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL TISSUES
ANIMALS
ANTIDEPRESSANTS
ANTIPYRETICS
ANTIPYRINE
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
BLOOD SUBSTITUTES
BODY
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CONDENSED AROMATICS
DEXTRAN
DISEASES
DOGS
DRUGS
DYES
ENDOTHELIUM
EXTRACELLULAR SPACE
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIPRAMINE
INDICATORS
INDOCYANINE GREEN
INDOLES
INJURIES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LUNGS
MAMMALS
MONOCARBOXYLIC ACIDS
NEUROREGULATORS
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
POLYSACCHARIDES
PSYCHOTROPIC DRUGS
PYRAZOLES
PYRAZOLINES
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SACCHARIDES
SEROTONIN
SPACE
SULFONATES
SYMPATHOMIMETICS
TISSUES
TOXICITY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TRYPTAMINES
UPTAKE
VERTEBRATES