Measuring the serotonin uptake site using (/sup 3/H)paroxetine--a new serotonin uptake inhibitor

Journal Article · Thu Dec 31 23:00:00 EST 1987 · Adv. Alcohol Subst. Abuse; (United States)

DOI:https://doi.org/10.1300/J251v07n03_17· OSTI ID:6409108

Gleiter, C H; Nutt, D J

Serotonin is an important neurotransmitter that may be involved in ethanol preference and dependence. It is possible to label the serotonin uptake site in brain using the tricyclic antidepressant imipramine, but this also binds to other sites. We have used the new high-affinity uptake blocker paroxetine to define binding to this site and report it to have advantages over imipramine as a ligand.

• Research Organization: National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD (USA)
• OSTI ID: 6409108
• Journal Information: Adv. Alcohol Subst. Abuse; (United States), Journal Name: Adv. Alcohol Subst. Abuse; (United States) Vol. 7:3-4; ISSN AASAD
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
AMINES
ANIMALS
ANTIDEPRESSANTS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZINES
AZOLES
BIOCHEMICAL REACTION KINETICS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CEREBRAL CORTEX
CEREBRUM
DRUGS
ETHANOL
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIPRAMINE
INDOLES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
METABOLISM
MICE
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIPERIDINES
PROTEINS
PSYCHOTROPIC DRUGS
PYRIDINES
PYRROLES
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
RECEPTORS
RODENTS
SEROTONIN
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TRYPTAMINES
UPTAKE
VERTEBRATES