Parkinson's disease: decreased density of /sup 3/H-imipramine and /sup 3/H-paroxetine binding sites in putamen

Journal Article · Mon Mar 31 23:00:00 EST 1986 · Neurology; (United States)

OSTI ID:5687357

Raisman, R; Cash, R; Agid, Y

The density of high-affinity /sup 3/H-imipramine and /sup 3/H-paroxetine binding sites (two serotonin-uptake blockers) was decreased in the putamen of parkinsonian patients. The correlation between serotonin levels and the number of /sup 3/H-imipramine and /sup 3/H-paroxetine binding sites suggests that they are located on serotoninergic nerve terminals and could be used to study serotoninergic innervation in the human brain. Since imipramine and paroxetine are powerful antidepressants, these results furthermore suggest that decreased serotoninergic transmission may be implicated in the pathophysiology of depression in Parkinson's disease.

• Research Organization: Laboratoire de Medecine Experimentale and Clinique de Neurologie et Neuropsychologie, Paris, France
• OSTI ID: 5687357
• Journal Information: Neurology; (United States), Journal Name: Neurology; (United States) Vol. 4; ISSN NEURA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AFFINITY
AMINES
ANTIDEPRESSANTS
AZINES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
DISEASES
DRUGS
HETEROCYCLIC COMPOUNDS
IMIPRAMINE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PATIENTS
PIPERIDINES
PROTEINS
PSYCHOTROPIC DRUGS
PYRIDINES
RECEPTORS
TRACER TECHNIQUES
TRITIUM COMPOUNDS