Noninvasive measurement of lung carbon-11-serotonin extraction in man

Journal Article · Mon Apr 01 04:00:00 EST 1991 · Journal of Nuclear Medicine; (USA)

OSTI ID:5802312

Coates, G; Firnau, G; Meyer, G J; Gratz, K F ^[1]

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1. McMaster Univ. Medical Centre, Hamilton, Ontario (Canada)

The fraction of serotonin extracted on a single passage through the lungs is being used as an early indicator of lung endothelial damage but the existing techniques require multiple arterial blood samples. We have developed a noninvasive technique to measure lung serotonin uptake in man. We utilized the double indicator diffusion principle, a positron camera, {sup 11}C-serotonin as the substrate, and {sup 11}CO-erythrocytes as the vascular marker. From regions of interest around each lung, we recorded time-activity curves in 0.5-sec frames for 30 sec after a bolus injection of first the vascular marker {sup 11}CO-erythrocytes and 10 min later {sup 11}C-serotonin. A second uptake measurement was made after imipramine 25-35 mg was infused intravenously. In three normal volunteers, the single-pass uptake of {sup 11}C-serotonin was 63.9% +/- 3.6%. This decreased in all subjects to a mean of 53.6% +/- 1.4% after imipramine. The rate of lung washout of {sup 11}C was also significantly prolonged after imipramine. This noninvasive technique can be used to measure lung serotonin uptake to detect early changes in a variety of conditions that alter the integrity of the pulmonary endothelium.

• OSTI ID: 5802312
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 32:4; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANIMAL TISSUES
ANTIDEPRESSANTS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MARKERS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CAMERAS
CARBON 11
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM AGENTS
DIAGNOSIS
DISEASES
DRUGS
ENDOTHELIUM
ERYTHROCYTES
EVEN-ODD NUCLEI
GAMMA CAMERAS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMAGE PROCESSING
IMIPRAMINE
INDOLES
ISOTOPES
LIGHT NUCLEI
LUNGS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NEUROREGULATORS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
POSITRON CAMERAS
PROCESSING
PSYCHOTROPIC DRUGS
PYRROLES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SEROTONIN
SYMPATHOMIMETICS
TISSUES
TRYPTAMINES
UPTAKE