Residual effects of polychlorinated biphenyls on adult nonhuman primates and their offspring

Journal Article · Tue Jan 01 04:00:00 EST 1980 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398009529830· OSTI ID:5098624

Allen, J R; Barsotti, D A; Carstens, L A

After 18 months of consuming a diet containing 2.5 and 5.0 ppM PCB (Aroclor 1248), during which they and their offspring experienced marked alterations in physical status, female rhesus monkeys were placed on a control diet for 1 y. During this year there was a decided improvement in their general body health and reproductive capabilities. Infants born to these animals were small at birth and during their postnatal life developed signs of PCB intoxication similar to those observed in their siblings born during the period of PCB exposure. These data indicate that the residual effects of low-level ingestion of PCBs by nonhuman primates persist for over 1 y after discontinuation of exposure. There are also indications that the fetal and neonatal monkeys born to PCB-exposed mothers are more severely affected for a longer period than are the adult female monkeys.

• Research Organization: Univ. of Wisconsin Medical School, Madison
• OSTI ID: 5098624
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 6:1; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
COMPARATIVE EVALUATIONS
DIET
FEMALES
FETUSES
INGESTION
INTAKE
MACACUS
MAMMALS
MONKEYS
NEONATES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PRIMATES
PROGENY
SENSITIVITY
TIME DEPENDENCE
VERTEBRATES