Comparison of some specific polychlorinated biphenyl isomers in human and monkey milk

Journal Article · Sun Nov 01 04:00:00 EST 1987 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01855848· OSTI ID:5378565

Mes, J; Marchand, L

The presence and levels of polychlorinated biphenyls (PCBs) in monkey milk have been reported earlier as part of studies which investigated the overall toxicity of PCBs in commercial Aroclors. Some of this information has served as a basis for an estimation of the potential health hazard of PCB contaminated breast milk to human infants. To further support such extrapolation from one primate situation to another, it would be desirable to know not only the levels of PCBs in the milk of these primates, but also the isomeric distribution in order to better evaluate the contribution of each isomer to the overall toxicity. A large concentration in breast milk of an isomer of relatively low toxicity may have the same effect on an infant as a smaller concentration of a highly toxic isomer. This paper compares the relative amounts of 29 selected PCB isomers in human milk and monkey milk samples. The selection of isomers was based on the most prevalent PCB isomers in human milk and represented approximately 80% of all reported isomers. In addition, Aroclor 1254, whose toxicity in monkeys has been investigated recently by several investigators, was analyzed for the same 29 selected PCB isomers.

• Research Organization: Health and Welfare Canada, Ontario
• OSTI ID: 5378565
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 39:5; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BODY FLUIDS
CHEMICAL ANALYSIS
CHLORINATED AROMATIC HYDROCARBONS
FOOD
HALOGENATED AROMATIC HYDROCARBONS
ISOMERS
MAMMALS
MAN
MATERIALS
MILK
MONKEYS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PRIMATES
QUANTITATIVE CHEMICAL ANALYSIS
VERTEBRATES