Mucinous gastric hyperplasia in a colony of rhesus monkeys (Macaca mulatta) induced by polychlorinated biphenyl (Aroclor 1254)
Journal Article
·
· Lab. Anim. Sci.; (United States)
OSTI ID:6782143
Since 1971, 45 of 259 male rhesus monkeys housed in a primate building have died of a chronic and progressive disease characterized by diarrhea, dehydration, weakness, gingivitis, emaciation, and alopecia. The principal necropsy finding in these monkeys, and in eight others killed for experimental purposes, was hypertrophic and hyperplastic mucinous gastropathy involving both the mucosa and submucosa. The toxic agent involved was identified as the polychlorinated biphenyl (PCB), Aroclor 1254. The suspected source of the toxic agent was a concrete sealer used during building construction.
- Research Organization:
- Department of Comparative Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC
- OSTI ID:
- 6782143
- Journal Information:
- Lab. Anim. Sci.; (United States), Journal Name: Lab. Anim. Sci.; (United States) Vol. 32:1; ISSN LBASA
- Country of Publication:
- United States
- Language:
- English
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Tue Oct 31 23:00:00 EST 1989
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OSTI ID:6521943
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BUILDING MATERIALS
CHLORINATED AROMATIC HYDROCARBONS
CONCRETES
DIGESTIVE SYSTEM
EPIDEMIOLOGY
GASTROINTESTINAL TRACT
HALOGENATED AROMATIC HYDROCARBONS
INDOOR AIR POLLUTION
LABORATORY ANIMALS
MACACUS
MAMMALS
MATERIALS
MEMBRANES
MONKEYS
MUCOUS MEMBRANES
NECROSIS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PATHOLOGICAL CHANGES
PATHOLOGY
POLLUTION
PRIMATES
SEALING MATERIALS
SENSITIVITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BUILDING MATERIALS
CHLORINATED AROMATIC HYDROCARBONS
CONCRETES
DIGESTIVE SYSTEM
EPIDEMIOLOGY
GASTROINTESTINAL TRACT
HALOGENATED AROMATIC HYDROCARBONS
INDOOR AIR POLLUTION
LABORATORY ANIMALS
MACACUS
MAMMALS
MATERIALS
MEMBRANES
MONKEYS
MUCOUS MEMBRANES
NECROSIS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PATHOLOGICAL CHANGES
PATHOLOGY
POLLUTION
PRIMATES
SEALING MATERIALS
SENSITIVITY
VERTEBRATES