Effects of Aroclor 1254 reg sign on hydrocortisone levels in adult Rhesus monkeys (Macaca mulatta)

Journal Article · Wed Nov 01 04:00:00 EST 1989 · Bulletin of Environmental Contamination and Toxicology; (USA)

DOI:https://doi.org/10.1007/BF01701985· OSTI ID:6521943

Loo, J C.K.; Tryphonas, H; Jordan, N; Brien, R; Karpinski, K R; Arnold, D L ^[1]

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1. Health Welfare Canada, Ottawa, Ontario (Canada)

Researchers, using female Sprague Dawley rats, reported the effects of chronic (5-7 months) oral dosing with Aroclor 1254{reg sign} (Polychlorinated biphenyls-PCB) on the serum levels of corticosterone, the principle glucocorticoid in rats. Their findings indicated that corticosterone levels were significantly depressed at dose levels of 479 {mu}g/kg bw/day and above. The objective of the present study was to determine the effects of PCB on the hydrocortisone levels in Rhesus monkey (Macaca mulatta) serum. In the monkey the controlling hormone is hydrocortisone which is identical to that of humans.

• OSTI ID: 6521943
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (USA), Journal Name: Bulletin of Environmental Contamination and Toxicology; (USA) Vol. 43:5; ISSN 0007-4861; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANIMALS
AROMATICS
BIOASSAY
BIOLOGICAL EFFECTS
CHLORINATED AROMATIC HYDROCARBONS
CHROMATOGRAPHY
CHRONIC EXPOSURE
CORTICOSTEROIDS
GLUCOCORTICOIDS
HALOGENATED AROMATIC HYDROCARBONS
HYDROCORTISONE
HYDROXY COMPOUNDS
KETONES
LIQUID COLUMN CHROMATOGRAPHY
MAMMALS
MONKEYS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PREGNANES
PRIMATES
RATS
RODENTS
SEPARATION PROCESSES
STEROIDS
VERTEBRATES