Induction of hepatocellular carcinoma in nonhuman primates by chemical carcinogens

Journal Article · Sat Dec 31 23:00:00 EST 1988 · Cancer Detection and Prevention; (USA)

OSTI ID:6936541

Adamson, R H ^[1]

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1. National Cancer Institute, National Institutes of Health, Bethesda, MD (USA)

Several compounds were evaluated in nonhuman primates for their potential to induce neoplasms, especially hepatocellular carcinoma (HCC). The compounds can be classified into three groups: food contaminants, model rodent carcinogens, and nitrosamines. All three compounds in the food contaminants group, namely, aflatoxin B1, sterigmatocystin, and methylazoxymethanol acetate, induced HCC. None of the model rodent carcinogens tested consistently induced HCC in rhesus and cynomolgus monkeys. Three of four nitrosamines evaluated induced HCC in rhesus and cynomolgus monkeys. One nitrosamine, diethylnitrosamine, is a predictable and potent inducer of HCC and is useful for establishment of a nonhuman primate model for numerous oncologic studies.

• OSTI ID: 6936541
• Journal Information: Cancer Detection and Prevention; (USA), Journal Name: Cancer Detection and Prevention; (USA) Vol. 14:2; ISSN 0361-090X; ISSN CDPRD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AFLATOXIN
AMINES
ANIMALS
BIOLOGICAL MODELS
CARCINOGENESIS
CARCINOGENS
DISEASES
HEPATOMAS
MAMMALS
MONKEYS
NEOPLASMS
NITROSAMINES
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PRIMATES
RODENTS
VERTEBRATES