Suppression of adoptive antituberculosis immunity by normal recipient animals
Adoptive immunity is poorly expressed in normal syngeneic mice. This phenomenon was studied by using experimental antituberculosis immunity as a model system representing pure cell-mediated immunity. Expression of adoptive immunity was facilitated by pretreating recipients with sublethal ionizing radiation (500 rads) or high doses (200 mg/kg) of cyclophosphamide or by using adult thymectomized, lethally irradiated, bone-marrow-reconstituted (TXB) mice. Adult thymectomy was less effective, and a low dose of cyclophosphamide (20 mg/kg) was completely ineffective. The beneficial effect of sublethal irradiation was reduced over time; it persisted for 4 weeks and was absent after 8 weeks. Attempts to restore the suppressed state of normal mice to sublethally irradiated mice by using normal spleen or thymus cells did not succeed. Even in rats, which express adoptive antituberculosis immunity without immunosuppressive treatment, the use of sublethally irradiated or TXB recipients potentiated adoptive immunity. It was concluded that suppression of adoptive immunization in normal recipient mice is mediated predominantly, if not exclusively, by T lymphocytes that are sensitive to a number of immunosuppressive agents. The suppressor cells are long-lived and can be regenerated from precursors that are resistant to 500 but not to 900 rads of ionizing radiation.
- Research Organization:
- Wayne State Univ. School of Medicine, Detroit, MI
- OSTI ID:
- 5096272
- Journal Information:
- Infect. Immun.; (United States), Journal Name: Infect. Immun.; (United States) Vol. 41:1; ISSN INFIB
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
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BLOOD CELLS
BODY FLUIDS
CHIMERAS
CONNECTIVE TISSUE CELLS
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ELECTROMAGNETIC RADIATION
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IONIZING RADIATIONS
LEUKOCYTES
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MAMMALS
MATERIALS
MEDICINE
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MOSAICISM
RADIATION CHIMERAS
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RADIOINDUCTION
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X RADIATION