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Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T cell-deficient recipients

Journal Article · · J. Exp. Med.; (United States)
DOI:https://doi.org/10.1084/jem.158.1.74· OSTI ID:6723030
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The results of this study demonstrate that spleen cells taken from mice at the height of the primary immune response to intravenous infection with Mycobacterium tuberculosis possess the capacity to transfer adoptive protection to M. tuberculosis-infected recipients, but only if these recipients are first rendered T cell-deficient, either by thymectomy and gamma irradiation, or by sublethal irradiation. A similar requirement was necessary to demonstrate the adoptive protection of the lungs after exposure to an acute aerosol-delivered M. tuberculosis infection. In both infectious models successful adoptive immunotherapy was shown to be mediated by T lymphocytes, which were acquired in the donor animals in response to the immunizing infection. It is proposed that the results of this study may serve as a basic model for the subsequent analysis of the nature of the T cell-mediated immune response to both systemic and aerogenic infections with M. tuberculosis.

Research Organization:
Trudeau Inst. Inc., Saranac Lake, NY
OSTI ID:
6723030
Journal Information:
J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 158:1; ISSN JEMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550700 -- Microbiology
551000 -- Physiological Systems
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IMMUNE REACTIONS
IMMUNOTHERAPY
IONIZING RADIATIONS
LEUKOCYTES
LUNGS
LYMPHOCYTES
MAMMALS
MATERIALS
MEDICINE
MICE
MICROORGANISMS
MYCOBACTERIUM
MYCOBACTERIUM TUBERCULOSIS
ORGANS
RADIATION EFFECTS
RADIATIONS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
SPLEEN CELLS
SURGERY
THERAPY
THYMECTOMY
VERTEBRATES