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Effects of cyclophosphamide and irradiation singly and in combination upon SaI growth in A/J mice

Journal Article · · Am. J. Pathol.; (United States)
OSTI ID:6499603
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The effects of various doses of cyclophosphamide and low-dose (15 rads) radiation upon the size of tumors caused by 10(4) Sarcoma I (SaI) cells was determined. In intact A/Jax (A/J) recipients, the effect of the two agents singly and in combination was found to be dependent especially upon the dosage of cyclophosphamide and the time of its administration in relation to tumor inoculation. In cell transfer experiments to adult thymectomized, lethally irradiated, bone-marrow-restored (ATxXBM) mice, the effects of cyclophosphamide and irradiation appeared to be either overlapping (low dosages of cyclophosphamide) or additive (dosages of cyclophosphamide greater than or equal to 50 mg/kg), suggesting that the two agents exert their influence in dissimilar fashion, perhaps by injuring different cell types with the same basic function. The most pronounced conjoint effects are seen when low dosages of cyclophosphamide are given 3 days after the adoptive transfer of spleen cells from mice pretreated with low-dose irradiation. The implications of this observation with respect to immunotherapy are discussed.

Research Organization:
Univ. of New Mexico School of Medicine, Albuquerque
OSTI ID:
6499603
Journal Information:
Am. J. Pathol.; (United States), Journal Name: Am. J. Pathol.; (United States) Vol. 2; ISSN AJPAA
Country of Publication:
United States
Language:
English

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Related Subjects

550600 -- Medicine
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CHEMOTHERAPY
COMBINED THERAPY
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL NEOPLASMS
IMMUNITY
IMMUNOTHERAPY
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MEDICINE
MICE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
RADIOTHERAPY
RODENTS
SARCOMAS
SPLEEN
THERAPY
TRANSPLANTS
VERTEBRATES