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Radiation-induced augmentation of the response of A/J mice to SaI tumor cells

Journal Article · · Am. J. Pathol.; (United States)
OSTI ID:6714017
; ; ;

Whole-body exposure of A/J mice to low doses (5-25 rads) of ionizing radiation immediately prior to the inoculation of 10(4) Sarcoma I (SaI) cells results in smaller tumors than are observed in sham-irradiated control animals. The irradiated group also contains a greater proportion of mice that fail to develop tumors or that demonstrate tumor regression. Low-dose augmentation is 1) less pronounced in recipients that have undergone splenectomy; 2) not evident in adult thymectomized-lethally irradiated-bone-marrow-restored (ATxXBM) animals, where the opposite effect is seen (eg, low-dose enhancement of tumor growth); and 3) abolished by the administration of normal syngeneic spleen cells unless the latter have been depleted of T cells. On this basis, a very radiosensitive T cell with suppressor activity is implicated in this phenomenon. Low-dose exposure at various times prior to tumor inoculation suggests that this cell regenerates in 5-10 days after irradiation.

Research Organization:
University of New Mexico School of Medicine, Albuquerque
OSTI ID:
6714017
Journal Information:
Am. J. Pathol.; (United States), Journal Name: Am. J. Pathol.; (United States) Vol. 108:1; ISSN AJPAA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
550900 -- Pathology
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CONNECTIVE TISSUE CELLS
DISEASES
DOSES
EXTERNAL IRRADIATION
GROWTH
HEMATOPOIETIC SYSTEM
IMMUNE REACTIONS
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MEDICINE
MICE
NEOPLASMS
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RODENTS
SOMATIC CELLS
SPLENECTOMY
SURGERY
THYMECTOMY
TISSUES
TUMOR CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION