Immunodeficiency syndromes: disorders of lymphocytopoiesis caused by environmental agents. Progress report

Technical Report · Tue Jan 01 04:00:00 EST 1985

OSTI ID:5093085

Rosse, C

This work has defined two experimental tumor systems in which there is an interaction between the bone marrow and certain neoplasms. These interactions are important in host responses against tumors. A major role belongs to bone marrow in the growth inhibition of methylcholanthrene-induced sarcomas. The bone marrow has been shown to contain Natural Tumor Growth Regulatory Cells (NTRC) that, in collaboration with immunocytes specifically sensitized to tumor-associated transplantation antigens, are capable of neutralizing that tumor. Select cell populations in mammary carcinomas of mice were shown to significantly alter the pattern of hemopoiesis and disturb lymphocyte and stem cell populations in the bone marrow. In addition fundamental studies are reported on lymphocyte production and differentiation in the bone marrow, thymus, and the periphery. 111 refs.

• Research Organization: Washington Univ., Seattle (USA). Dept. of Biological Structure
• DOE Contract Number: AT06-79EV10270
• OSTI ID: 5093085
• Report Number(s): DOE/EV/10270-6; ON: DE87001649
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
AIDS
ANIMAL CELLS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY FLUIDS
BONE MARROW CELLS
CELL CULTURES
CELL DIFFERENTIATION
CELL PROLIFERATION
CHIMERAS
CLONE CELLS
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DISEASES
EXPERIMENTAL NEOPLASMS
FUNCTIONS
GRAFT-HOST REACTION
GROWTH FACTORS
HEMIC DISEASES
IMMUNOSUPPRESSION
INFECTIOUS DISEASES
LEUKOCYTES
LEUKOPOIESIS
LYMPHOCYTES
LYMPHOKINES
MATERIALS
MITOGENS
MOSAICISM
ORGANIC COMPOUNDS
PROTEINS
RESPONSE MODIFYING FACTORS
SOMATIC CELLS
VIRAL DISEASES