Marrow-tumor interactions: the role of the bone marrow in controlling chemically induced tumors. 1983 annual progress report

Technical Report · Sat Jan 01 04:00:00 EST 1983

OSTI ID:5712607

Our work has defined two experimental tumor systems in which we have shown that there is interaction between the bone marrow and certain neoplasms. We have documented that these interactions are important in host responses against tumors. Our experiments have assigned a major role to bone marrow in the growth inhibition of methylcholanthrene-induced (MCA) sarcomas. We have discovered that the bone marrow contains Natural Tumor Growth Regulatory Cells (NTRC) that in collaboration with immunocytes specifially sensitized to a tumor are capable of neutralizing that tumor. In addition, we have shown that a mammary carcinoma of mice significantly alters the pattern of hemopoiesis and disturbs lymphocyte and stem populations in the bone marrow. Our approach has been to pursue multiple convergent lines of attack, since the host response against various cancers is complex, relying on the interaction of several cell types which exercise their tumor neutralization effect probably through various mechanisms. A unique component of our work is the investigation of the influence neoplasms exert on the production of various types of bone marrow cells which can function or can differentiate into cells that participate in the host's antitumor responses. The focus of the work has remained the same and we have continued to define the identity of the bone marrow derived cells involved in tumor neutralization and the mechanisms through which they exert their function.

• Research Organization: Washington Univ., Seattle (USA). School of Medicine
• DOE Contract Number: AT06-79EV10270
• OSTI ID: 5712607
• Report Number(s): DOE/EV/10270-4; ON: DE84001116
• Country of Publication: United States
• Language: English

Related Subjects

3-METHYLCHOLANTHRENE
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AROMATICS
BODY
BONE MARROW
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DISEASES
HEMATOPOIETIC SYSTEM
HYDROCARBONS
IMMUNE REACTIONS
INHIBITION
MAMMALS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
POLYCYCLIC AROMATIC HYDROCARBONS
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES