Marrow tumor interactions: the role of the bone marrow in controlling chemically induced tumors. Progress report, July 1, 1980-July 31, 1981
Technical Report
·
OSTI ID:6289666
Progress is outlined below. (1) Bone marrow has been shown to uniquely contribute to the neutralization of immunogenic, chemically induced neoplasms by producing Natural Tumor Growth Regulatory cells. These cells are not differentiated T or B lymphocytes, recognizable by conventional markers, nor are they apparently macrophages. Current work will characterize these cells. (2) Experimental evidence shows that the bone marrow can generate cytotoxic T lymphocytes in vitro on a much larger scale than previous systems have been able to document. The development and refinement of in vitro assays will resolve what role each of these cell types contributes to the antitumor effect mediated by bone marrow cells. (3) CE mammary carcinoma has been shown not to generate immunity detectable by conventional assays. Studies will continue to test whether or not the mammary carcinoma engages immune responses, perhaps through the expression of viral antigens. (4) The development of immunogenic methylcholanthrene induced sarcomas in BALB/c x CE F1 mice which support the mammary carcinoma now enables testing whether or not growing neoplasms influence bone marrow functions. (5) Tests have demonstrated that the mammary carcinoma alters cell populations of lymphocytes in lymphoid organs and is mainly a consequence of reduced lymphocyte production by the bone marrow. (6) Studies continue on the effect tumors exert on hemopoiesis.
- Research Organization:
- Washington Univ., Seattle (USA)
- DOE Contract Number:
- AT06-79EV10270
- OSTI ID:
- 6289666
- Report Number(s):
- DOE/EV/10270-T1; ON: DE81030317
- Country of Publication:
- United States
- Language:
- English
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