Immunodeficiency syndromes: Disorder of lymphocytopoiesis caused by environmental agents: Volume 1, comprehensive progress report

Technical Report · Fri Jan 01 04:00:00 EST 1988

OSTI ID:7138596

Rosse, C

The studies we have performed have provided a substantial database that supports these beliefs. Our work sponsored by DOE has defined experimental tumor systems in which we have known that there is interaction between the bone marrow and certain neoplasms. We have documents that these interactions are important in host responses against tumors, and that certain tumors profoundly alter the production of several types of cells in the lymphopoiesis in an experimental model of graft-vs-host disease (GVHD) that develops as a consequence of bone marrow transplantation between H-2 identical mouse strains that differ in monorhistocompatibility antigens (minor HA). Parallel with the experimental systems that investigated interactions between the bone marrow and tumors, we have maintained an active program concerned with fundamental studies of lymphocyte production and differentation in the bone marrow, thymus, and periphery. The elucidation of the mechanisms that regulate the differentiation program of T, B, and natural killer (NK) cells remains a requisite for understanding at what level carcinogenic and noncarcinogenic environmental factors exert their influence on the lymphomyeloid complex. We have made notable progress with studies concerning the regulation of B lymphocyte production, the maintenance of T cell precursors in the bone marrow and thymus and the cell traffic between these organs, and especially in unravelling the lineage relationship, turnover, and functional heterogeneity of NK cells. 173 refs., 11 figs., 14 tabs.

• Research Organization: Washington Univ., Seattle (USA). Dept. of Biological Structure
• DOE Contract Number: FG06-86ER60409
• OSTI ID: 7138596
• Report Number(s): DOE/ER/60409-3-Vol.1; ON: DE88012949
• Country of Publication: United States
• Language: English

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