Immunodeficiency syndromes: Disorders of lymphocytopoiesis caused by environmental agents: Annual progress report

Technical Report · Thu Jan 01 04:00:00 EST 1987

OSTI ID:5649837

Rosse, C

These publications and our current research activities focus mainly on questions of lymphocyte production and regulation. Our activities during the past year have been characterized by collaboration and a multi-faceted approach. We have continued our work, which elucidates the modulatory influence of the CE mammry carcinoma (CEmaca) on lymphocytopoiesis and on bone metabolism. We have paid particular attention to natural killer (NK) cells in this experimental system. We developed in vitro techniques that support clonal growth of the tumor and make possible the in vitro maintenance of microenvironments that support long-term lymphocytopoiesis. We have defined NK cell precursors and the modulation of NK cell production. We have identified early T cell progenitors in the fetal thymus and bone marrow and have defined the stromal elements of the thymus with an important role in thymic lymphocytopoiesis. We are beginning our inquiry into the molecular mechanisms that control T cell development at the genomic level. The experimental system for this approach has been a retrovirus-induced murine thymoma. The discovery of a viral enhancer element in this system, which is specific for the T lineage, holds considerable promise for investigating T lymphocyte development. 2 figs., 11 tabs.

• Research Organization: Washington Univ., Seattle (USA)
• DOE Contract Number: FG06-86ER60409
• OSTI ID: 5649837
• Report Number(s): DOE/ER/60409-2; ON: DE88004120
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
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MAMMALS
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RADIOINDUCTION
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SOMATIC CELLS
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