Thymic lymphocyte differentiation and thymic leukemogenesis
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Henry Kaplan helped establish the fields of lymphocyte biology and viral leukemogenesis by his early and continuing studies on radiation leukemogenesis. As one of Henry's students I carried on these dual preoccupations with thymic lymphocytopoiesis and thymic lymphomagenesis. This communication demonstrates that 1) thymic lymphoctyes are derived from bone marrow precursors which lack any T cell markers; 2) these bone marrow cells (or their clonogenic subsets) can give rise to either thymic cortical plus medullary progeny, or medullary progeny alone; 3) thymic lymphocytes mature in contract with 3-5 classes of monlymphoid cells and one of these subsets, cortical dendritic epithelial cells, express an unusual distribution of MHC antigen; 4) the population of cells which are poised to emigrate from the thymus are a unique subset of cortical cells which possess peripheral lymphoid organ homing receptors; and 5) the thymic target cells for retrovirus lymphomagenesis express highly specific retrovirus receptors that are analogous (and perhaps synonymous) with antigen-specific T cell receptors.
- Research Organization:
- Stanford Univ. School of Medicine, CA
- OSTI ID:
- 5863272
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:1; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CARCINOGENESIS
CELL DIFFERENTIATION
CONNECTIVE TISSUE CELLS
HEMATOPOIETIC SYSTEM
LEUKEMIA VIRUSES
LEUKEMOGENESIS
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MICROORGANISMS
ONCOGENIC VIRUSES
ORGANS
PARASITES
PATHOGENESIS
PHENOTYPE
RADIOINDUCTION
RECEPTORS
RODENTS
SOMATIC CELLS
THYMUS
TISSUES
VERTEBRATES
VIRUSES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CARCINOGENESIS
CELL DIFFERENTIATION
CONNECTIVE TISSUE CELLS
HEMATOPOIETIC SYSTEM
LEUKEMIA VIRUSES
LEUKEMOGENESIS
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MICROORGANISMS
ONCOGENIC VIRUSES
ORGANS
PARASITES
PATHOGENESIS
PHENOTYPE
RADIOINDUCTION
RECEPTORS
RODENTS
SOMATIC CELLS
THYMUS
TISSUES
VERTEBRATES
VIRUSES