Interleukin-1 beta gene deregulation associated with chromosomal rearrangement: A candidate initiating event for murine radiation-myeloid leukemogenesis

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Mol. Carcinog; (USA)

DOI:https://doi.org/10.1002/mc.2940020409· OSTI ID:5080128

Silver, A; Boultwood, J; Breckon, G; Masson, W; Adam, J; Shaw, A R; Cox, R ^[1]

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1. Medical Research Council Radiobiology Unit, Chilton, Didcot (England)

The incidence of acute myeloid leukemia (AML) in CBA/H mice following exposure to single acute doses of ionizing radiation has previously been determined. A high proportion of these AMLs are characterized by rearrangement of murine chromosome 2 in the C2 and/or E5-F regions, and there is evidence that these events are a direct consequence of radiation damage to multipotential hemopoietic cells. Using a combination of in situ chromosome hybridization and mRNA analyses, we show that the cytokine gene interleukin-1 beta (IL-1 beta) is encoded in the chromosome 2 F region and is translocated in a chromosome 2---2 rearrangement in an x-ray-induced AML (N36). Also, IL-1 beta is specifically deregulated in N36 and in two other chromosome 2-rearranged AMLs but not in a fourth, which has two cytogenetically normal chromosome 2 copies. We suggest that radiation-induced specific chromosome 2 rearrangement associated with IL-1 beta deregulation may initiate murine leukemogenesis through the uncoupling of normal proliferative control mechanisms in multipotential hemopoietic cells.

• OSTI ID: 5080128
• Journal Information: Mol. Carcinog; (USA), Journal Name: Mol. Carcinog; (USA) Vol. 2:4; ISSN 0899-1987; ISSN XY971
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHROMOSOMAL ABERRATIONS
DISEASES
ELECTROMAGNETIC RADIATION
GENE REGULATION
GENES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GROWTH FACTORS
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
IONIZING RADIATIONS
IRRADIATION
KARYOTYPE
LEUKEMIA
LYMPHOKINES
MAMMALS
MICE
MITOGENS
MUTATIONS
MYELOID LEUKEMIA
NEOPLASMS
ORGANIC COMPOUNDS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
VERTEBRATES
X RADIATION