Chromosomal abnormalities in neutron-induced acute myeloid leukemias in CBA/H mice

Journal Article · Sun Sep 01 04:00:00 EDT 1996 · Radiation Research

DOI:https://doi.org/10.2307/3579467· OSTI ID:381108

Bouffler, S D ^[1]; Meijne, E I.M.; Huiskamp, R ^[2]

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1. National Radiological Protection Board, Oxon (United Kingdom)
2. Netherlands Energy Research Foundation (ECN), Petten (Netherlands); and others

Acute myeloid leukemias (AMLs) induced in CBA/H mice by 1 MeV fission neutrons have been examined for chromosomal abnormalities by G-band analysis. In common with X-ray- and {alpha}-particle-induced AMLs in CBA/H mice, more than 90% (16/17) of the myeloid leukemias had chromosome 2 abnormalities, in this case, all interstitial deletions. Chromosome 2 breakpoints were not wholly consistent, but clustering in three specific G-band regions was observed. Very distal (H-region) breakpoints were more common in the neutron AMLs than in X-ray- or {alpha}-particle-induced leukemias. These data indicate that neutron-induced AMLs in CBA/H mice are not characterized by a specific chromosome deletion but that a variety of chromosome 2 deletion types are associated with the disease. Trisomy of chromosome 1 (12.5% AMLs) and aneusomy of chromosomes 6 (31% AMLs) and Y (37.5% AMLs) were noted. While chromatid breakage was observed occasionally in neutron-induced AML, no clear indications of persistent chromosomal instability or high levels of stable chromosomal change were apparent. 19 refs., 1 fig., 1 tab.

• Sponsoring Organization: USDOE
• OSTI ID: 381108
• Journal Information: Radiation Research, Journal Name: Radiation Research Journal Issue: 3 Vol. 146; ISSN 0033-7587; ISSN RAREAE
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL RADIATION EFFECTS
CHROMOSOMAL ABERRATIONS
CHROMOSOME BREAKAGE
FISSION NEUTRONS
MICE
MYELOID LEUKEMIA