Altered glucose kinetics in diabetic rats during Gram-negative infection

Journal Article · Sat Aug 01 04:00:00 EDT 1987 · American Journal of Physiology; (USA)

OSTI ID:5060146

Lang, C H; Dobrescu, C; Bagby, G J; Spitzer, J J ^[1]

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1. Louisiana State Univ. Medical Center, New Orleans (USA)

The present study examined the purported exacerbating effect of sepsis on glucose metabolism in diabetes. Diabetes was induced in rats by an intravenous injection of 70 or 45 mg/kg streptozotocin. The higher dose produced severe diabetes, whereas the lower dose of streptozotocin produced a miler, latent diabetes. After a chronic diabetic state had developed for 4 wk, rats had catheters implanted and sepsis induced by intraperitoneal injections of live Escherichia coli. After 24 h of sepsis the blood glucose concentration was unchanged in nondiabetics and latent diabetics, but glucose decreased from 15 to 8 mM in the septic severe diabetic group. This decrease in blood glucose was not accompanied by alterations in the plasma insulin concentration. Glucose turnover, assessed by the constant intravenous infusion of (6-{sup 3}H)- and (U-{sup 14}C)glucose, was elevated in the severe diabetic group, compared with either latent diabetics or nondiabetics. Sepsis increased the rate of glucose disappearance in nondiabetic rats but had no effect in either group of diabetic animals. Sepsis also failed to alter the insulinogenic index, used to estimate the insulin secretory capacity, in diabetic rats. Thus the present study suggests that the imposition of nonlethal Gram-negative sepsis on severe diabetic animals does not further impair glucose homeostasis and that the milder latent diabetes was not converted to a more severe diabetic state by the septic challenge.

• OSTI ID: 5060146
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 253:2; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
BACTERIA
CARBOHYDRATES
CARBON 14 COMPOUNDS
DIABETES MELLITUS
DISEASES
ENDOCRINE DISEASES
ESCHERICHIA COLI
GLUCOSE
HEXOSES
HOMEOSTASIS
HYDROGEN COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
METABOLIC DISEASES
METABOLISM
MICROORGANISMS
MONOSACCHARIDES
ORGANIC COMPOUNDS
PATHOGENESIS
RATS
RODENTS
SACCHARIDES
SEPTICEMIA
TRITIUM COMPOUNDS
VERTEBRATES