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D-(U-11C)glucose uptake and metabolism in the brain of insulin-dependent diabetic subjects

Journal Article · · American Journal of Physiology; (USA)
OSTI ID:6868980
; ; ; ; ;  [1]
  1. Karolinska Hospital and Institute, Stockholm (Sweden)
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We used D-(U-11C)glucose to evaluate transport and metabolism of glucose in the brain in eight nondiabetic and six insulin-dependent diabetes mellitus (IDDM) subjects. IDDM subjects were treated by continuous subcutaneous insulin infusion. Blood glucose was regulated by a Biostator-controlled glucose infusion during a constant insulin infusion. D-(U-11C)-glucose was injected for positron emission tomography studies during normoglycemia as well as during moderate hypoglycemia (arterial plasma glucose 2.74 +/- 0.14 in nondiabetic and 2.80 +/- 0.26 mmol/l (means +/- SE) in IDDM subjects). Levels of free insulin were constant and similar in both groups. The tracer data were analyzed using a three-compartment model with a fixed correction for 11CO2 egression. During normoglycemia the influx rate constant (k1) and blood-brain glucose flux did not differ between the two groups. During hypoglycemia k1 increased significantly and similarly in both groups (from 0.061 +/- 0.007 to 0.090 +/- 0.006 in nondiabetic and from 0.061 +/- 0.006 to 0.093 +/- 0.013 ml.g-1.min-1 in IDDM subjects). During normoglycemia the tracer-calculated metabolism of glucose was higher in the whole brain in the nondiabetic than in the diabetic subjects (22.0 +/- 1.9 vs. 15.6 +/- 1.1 mumol.100 g-1.min-1, P less than 0.01). During hypoglycemia tracer-calculated metabolism was decreased by 40% in nondiabetic subjects and by 28% in diabetic subjects. The results indicate that uptake of glucose is normal, but some aspect of glucose metabolism is abnormal in a group of well-controlled IDDM subjects.
OSTI ID:
6868980
Journal Information:
American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 258; ISSN 0002-9513; ISSN AJPHA
Country of Publication:
United States
Language:
English

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Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARBOHYDRATES
CARBON 11
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIABETES MELLITUS
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
ENDOCRINE DISEASES
EVEN-ODD NUCLEI
GLUCOSE
HEXOSES
HORMONES
INSULIN
ISOTOPES
LIGHT NUCLEI
MAMMALS
MAN
MATHEMATICAL MODELS
MEMBRANE TRANSPORT
METABOLIC DISEASES
METABOLISM
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PEPTIDE HORMONES
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
VERTEBRATES