Evidence for increased peroxidative activity in muscles from streptozotocin-diabetic rats
The ability of cardiac and skeletal muscles from diabetic rats to metabolize superoxide and hydrogen peroxide was determined by the activities of superoxide dismutase (SOD) and catalase, respectively. Male and female Sprague-Dawley rats, 43 days old, were made diabetic with a single intravenous injection of streptozotocin (70 mg/kg body weight). On the 80th day after injection the blood glucose concentration of these rats was increased fourfold, and the plasma insulin concentration was decreased four- to fivefold compared to controls. Body weights of male diabetic rats were 61% and those of female diabetic rats were 66% of their ad libitum-fed controls. The seven different skeletal muscles examined weighed less in the diabetic rats than in controls of the same age and body weight. Comparison to the body weight controls allowed the distinction of specific effects due to lack of insulin from effects due to retardation in muscle growth. Increased catalase activity in all muscles examined from diabetic rats (plantaris, gastrocnemius, and heart) suggested a response in catalase activity similar to that of starved rats. SOD activity was not altered in the diabetic rat skeletal muscles and erythrocytes, but was somewhat decreased in the heart.
- Research Organization:
- Univ. of Minnesota, St. Paul
- OSTI ID:
- 5774790
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 176:1; ISSN PSEBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CATALASE
DATA
DIABETES MELLITUS
DISEASES
DRUGS
ENDOCRINE DISEASES
ENZYME ACTIVITY
ENZYMES
EXPERIMENTAL DATA
GLUCOSE
HEART
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HEXOSES
HORMONES
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
INFORMATION
INJECTION
INSULIN
INTAKE
INTRAVENOUS INJECTION
MAMMALS
METABOLIC DISEASES
METABOLISM
MONOSACCHARIDES
MUSCLES
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PEPTIDE HORMONES
PEROXIDASES
PEROXIDES
PHYSIOLOGY
PORPHYRINS
RADICALS
RATS
RODENTS
SACCHARIDES
SUPEROXIDE DISMUTASE
SUPEROXIDE RADICALS
VERTEBRATES
WEIGHT