Intestinal zinc transport: influence of streptozotocin-induced diabetes, insulin and arachidonic acid

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(88)90460-2· OSTI ID:5394274

Song, M K; Mooradian, A D

The influence of arachidonic acid (AA) on the zinc flux rates of jejunal segments, isolated from streptozotocin-induced diabetic rats injected with saline or with insulin, was investigated using an Ussing chamber technique. Although the zinc flux rates from mucose-to-serosa (J/sub ms/) of normal rats were inhibited by addition of 5 ..mu..M AA to the jejunal segment bathing medium, AA had no effect on the J/sub ms/ of diabetic rats either with or without insulin treatment. Induction of diabetes also significantly reduces J/sub ms/, but 3 day insulin treatment did not reverse this effect. Addition of AA to the serosal side did not significantly alter the zinc flux rate from serosa-to-mucosa (J/sub sm/) in either control, diabetic or diabetic rats treated with insulin. The net zinc absorption rate (J/sub net/) of jejunal segments was decreased in diabetic rats compared to controls, but normalization of blood glucose with 3 day insulin treatment did not increase J/sub net/. Addition of AA was associated with a tendency to increase zinc uptake capacity. This change reached statistical significance in insulin treated diabetic rats. Short-circuit current (I/sub sc/) for diabetic rats was increased compared to controls but addition of AA to the mucosal side bathing medium decreased I/sub sc/ in all groups. 32 references, 3 figures, 1 table.

• Research Organization: Veterans Administration Medical Center, Sepulveda, CA
• OSTI ID: 5394274
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 42:6; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

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560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
ARACHIDONIC ACID
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BODY
CARBOXYLIC ACIDS
DIABETES MELLITUS
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
ENDOCRINE DISEASES
FUNCTIONS
GASTROINTESTINAL TRACT
HORMONES
INSULIN
INTESTINAL ABSORPTION
INTESTINES
MAMMALS
MEMBRANE TRANSPORT
METABOLIC DISEASES
METALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
RATS
RODENTS
SMALL INTESTINE
UPTAKE
VERTEBRATES
ZINC